Influence of aerobic exercise training on mice gut microbiota in Parkinson's disease

Accumulating evidence shows that gut microbial dysbiosis may represent a risk factor for Parkinson's disease (PD). Exercise has positive effect on microbiota in general. The of aerobic exercise training (AET) the environment PD remains to be explored. Here, we performed 16S rRNA gene sequencing feces from sham operated-mice (sham), mice model, and receiving AET (AET). Results indicated had no remarkable species richness bacterial diversity mice. relative abundance Bacteroidetes was reduced, while Firmicutes, Actinobacteria, Lactobacillaceae, Streptococcaceae, Lactobacillus, Streptococcus, Lactococcus, Lysinibacillus, Pelomonas, Prevotellaceae_UCG?001 were increased compared with those operated-mice, whereas partly rescued their abundance. Additionally, composition proportion beneficial Lactobacillus_gasseri uncultured_Erysipelotrichales_bacterium significantly Moreover, discriminative bacteria, such as Bacilli, Lactobacillales, Lactococcus identified specific taxon Here provide can improve